Effect of intradermal injection of glutathione and tranexamic acid in the treatment of chloasma / 中国基层医药

ABSTRACT

Objective To explore the effect of intradermal injection of glutathione and tranexamic acid in the treatment of chloasma.Methods From July 2016 to May 2018,96 patients with chloasma admitted to the dermatology department of the Central Hospital of Shengli Oil Field were selected and randomly divided into control group and observation group,with 48 cases in each group.The macular color and area,curative effect(basic cure,obvious effect,improvement,ineffective),adverse reactions (acupuncture reaction,recurrence after treatment,gastrointestinal tract reaction,oral ulcer and menstrual quantity reduction) were observed.Results After treatment,both two groups showed significant improvement in chloasma color score and chloasma area (t =9.258,10.774,all P ＜ 0.05;t =11.673,12.66,all P ＜ 0.05).After treatment,the color score and area of chloasma in the observation group were (1.13 ± 0.91) points,(1.62 ± 1.26) cm2,respectively,which were significantly lower than those in the control group[(0.78 ± 0.62) points,(0.80 ± 0.83) cm2,t =2.132,3.641,all P ＜ 0.05].The total effective rate of the observation group was 91.67％,which was significantly higher than 62.50％ of the control group(x2 =11.558,P ＜ 0.05).Both two groups experienced needle sickness during treatment.After treatment,the gastrointestinal tract reaction,oral ulcer and the influence of menstruation occurred in the observation group.However,differences in adverse reaction between the two groups were not significant (all P ＞ 0.05).Conclusion The combination of tranexamic acid and glutathione has significant effect on reducing the color of patients' chloasma and reducing the area of patients' chloasma.In terms of treatment effect,the combined injection group is significantly superior to the conventional treatment group,and the combined injection group has a certain safety.