Two Cases of Wernicke's Encephalopathy That Developed during Total Parenteral Nutrition in Colon Cancer Patients Treated with 5-Fluorouracil-based Chemotherapy / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 158-163, 2014.
Article
in Korean
| WPRIM
| ID: wpr-74442
ABSTRACT
Wernicke's encephalopathy (WE) caused by thiamine deficiency is an acute neurological disorder. Clinically, the classic triad of WE consists of ophthalmoplegia, ataxia, and mental status changes. Thiamine deficiency is known to occur commonly in chronic alcoholic patients. Sometimes, it can occur in patients after gastrointestinal surgery and in those with malabsorption. In addition, patients undergoing renal dialysis, suffering from hyperemesis gravidarum, receiving total parenteral nutrition (TPN), and being treated with chemotherapeutic agents are also prone to develop thiamine deficiency. Herein, we report two cases of WE that developed following simultaneous 5-fluorouracil (5-FU) chemotherapy and TPN in colon cancer patients which was successfully treated with thiamine administration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thiamine
/
Vitamin B Complex
/
Wernicke Encephalopathy
/
Brain
/
Magnetic Resonance Imaging
/
Parenteral Nutrition, Total
/
Colonic Neoplasms
/
Fluorouracil
/
Antimetabolites, Antineoplastic
Limits:
Adult
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2014
Type:
Article
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