Clinical effect of anisodamine combined with gabapentin on painful diabetic neuropathy / 中国基层医药

ABSTRACT

Objective To assess the clinical effect of anisodamine combined with gabapentin on painful diabetic neuropathy(PDN).Methods From June 2013 to February 2017,120 patients with PDN in the Fifth People's Hospital of Datong were assigned into anisodamine group,gabapentin group and combined group according to the digital table,with 40 cases in each group,the patients were treated with anisodamine,gabapentin and combination therapy respectively.The abnormal foot plantar pressure,MCV and SCV of median nerve and common peroneus nerve,VAS and total effective rate of three groups were compared.Results After treatment,the indicators of the combined group were improved more significantly than those of the anisodamine group and gabapentin group in abnormal foot plantar pressure[(6.10 ± 1.66) vs.(10.80 ± 2.64) vs.(6.37 ± 1.44),F =14.602,P ＜ 0.01],total effective rate (92.5％ vs.62.2％ vs.75.0％,x2 =10.155,P=0.006),MCV[(50.33 ±5.54)m/s vs.(41.12 ±4.47)m/s vs.(42.32 ±4.40)m/s,F=9.404,P =0.001],and SCV of median nerve[(48.51 ±6.19)m/s vs.(41.81 ±5.72)m/s vs.(41.76 ± 7.17) m/s,F =3.728,P =0.037],MCV of common peroneus nerve [(40.60 ± 5.69) m/s vs.(32.04 ± 4.47) m/s vs.(33.52 ± 7.76) m/s,F =5.614,P =0.009] and SCV of common peroneus nerve [(42.72 ± 4.97) m/s vs.(36.21 ± 6.16) m/s vs.(35.45 ± 5.54) m/s,F =4.265,P =0.025].After treatment,the VAS scores of the three groups decreased,which were (4.49 ± 1.61) points,(5.82 ± 1.58) points,(6.37 ± 1.44) points,respectively,the difference was statistically significant (F =14.602,P =0.000),and the decrease was more significant in the combined group.Conclusion Compared with the anisodamine group and gabapentin group,the combined treatment is more effective on PDN.