Effect of nabuprofen and sufentanil on analgesia score and sedation score in patients with total hip arthroplasty / 中国基层医药

ABSTRACT

Objective To analyze the effects of nabuprofen combined with sufentanil on Ramsay sedation score,visual analogue scale (VAS) and analgesic effect in patients undergoing total hip arthroplasty (THA) for patient-controlled intravenous analgesia (PCIA).Methods From January 2017 to December 2017,72 patients with THA in the Department of Orthopedics from the People's Hospital of Linfen were divided into three groupsA group was given nabuprofen,B group was given sufentanil,C group was given nabuprofen + sufentanil,with 24 cases in each group.Ramsay sedation score,VAS score and analgesic effect were compared among the three groups before and after operation.Results The Ramsay sedation scores of A group at 3,12 and 24 hours after operation were (2.78 ±0.32) points,(2.59 ± 0.40) points and (2.4 ± 0.26) points,respectively,and the Ramsay sedation scores of C group at 3,12 and 24 hours after operation were (2.37 ± 0.24) points,(2.0 ± 0.15) points,(1.89 ± 0.22) points,respectively,which were decreased significantly compared with those of B group at the same time point [(3.07 ± 0.58) points,(3.01 ±0.62)points and (2.73 ±0.47)points] (Fbetween group =6.83,Pbetween group =0.01;Ftime point =7.24,Ptime point ＜0.01;Fbeyween group· time point =0.69,Pbetween group.timepoint =0.40).The VAS scores of group B at 3,12 and 24 hours after operation were (2.40 ± 0.72) points,(1.98 ± 0.57) points and (1.24 ± 0.38) points,respectively,and the VAS scores of C group at 3,12 and 24 hours after operation were (2.35 ± 0.75) points,(1.74 ± 0.46) points and (1.18 ±0.26) points,respectively,which were decreased significantly compared with those of A group at the same time point [(3.35 ± 0.59) points,(3.18 ± 0.46) points and (3.01 ± 0.33) points] (Fbetween group =7.02,Pbetween group ＜ 0.01;Ftime point =5.42,Ptime point =0.02;Fbetween group· time point =0.39,Pbetween gronp· time point =0.68).There was statistically significant difference among the three groups (x2 =7.66,P ＜0.05).The analgesic satisfaction of C group (91.67％) was significantly higher than that of A group (58.33％) and B group (62.50％) (x2 =5.44,4.25,all P ＜ 0.05).Conclusion The sedative and analgesic effects of PCIA nabuprofen combined with sufentanil for patients with THA are definite and comfortable,which can effectively alleviate pain,so it has a definite clinical application value.