Your browser doesn't support javascript.
loading
Effect of Gamma Knife Coupled with Conventional Chemotherapy on the Clinical Efficacy and Immune Function in Patients with Esophageal Carcinoma Complicated by Loco-Regional Lymph Node Metastasis / 中国医科大学学报
Journal of China Medical University ; (12): 205-209,215, 2019.
Article in Chinese | WPRIM | ID: wpr-744826
ABSTRACT
Objective To observe patients with esophageal squamous cell carcinoma [ESCC, without distant lymph node metastasis (LM) ], who had local LM after radiotherapy and therefore were treated with gamma knife combined with conventional chemotherapy (5-fluorouracil +cisplatin); to evaluate the clinical efficacy in these patients after treatment; and to record adverse reactions. Methods A total of 120 patients with ESCC who underwent radical radiotherapy (with local LM thereafter) without distant LM were randomly divided into control (n = 60; 55 completed the procedure successfully) and observation (n = 60; 50 completed the procedure successfully) groups. The control group was treated with gamma knife, whereas the observation group was given chemotherapy (5-fluorouracil and cisplatin) in addition to the basic gamma knife for 4 courses of treatment. The clinical efficacy of the two groups was compared at the end of treatment, followed by detection of immunological indicators (cellular and humoral immunity) and recording of adverse reactions. Results After treatment, the short-term clinical efficacy in the observation group was found to be better than that in the control group but held no statistical significance (P> 0.05). However, the long-term clinical efficacy was significantly enhanced in the observation group than in the control group (P < 0.05). After treatment, the immunological indicators (cellular and humoral immunity) of the two groups were substantially improved post treatment (P < 0.05), exhibiting remarkable enhancement in the observation group compared with the control group (P <0.05). Remission rate of the clinical symptoms did not vary significantly between the two groups after treatment (P> 0.05). Adverse reactions such as leukopenia, decreased platelet count, nausea, and vomiting were observed during the course of treatment for both the groups, lacking any significant difference (P> 0.05). Conclusion Gamma knife coupled with chemotherapy (5-fluorouracil + cisplatin) can improve the treatment efficiency in ESCC patients with local LM following radical radiotherapy.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of China Medical University Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of China Medical University Year: 2019 Type: Article