Application of vincristine-loaded platelet therapy in three dogs with refractory immune-mediated thrombocytopenia
Journal of Veterinary Science
;
: 127-130, 2015.
Article
in English
| WPRIM
| ID: wpr-74485
ABSTRACT
Three dogs presented with refractory immune-mediated thrombocytopenia (IMT). All patients failed to respond to prednisone, which is considered a mainstay of immunosuppressive therapy. Vincristine-loaded platelets (VLPs), which act selectively on mononuclear phagocytes,were introduced. After the VLPs were transfused, two dogs responded quickly withimproved clinical signs while the third dogwith recurrent IMT was euthanized due to its deteriorating condition. This case report describesthe efficacy of VLP therapy in refractory IMT patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vincristine
/
Purpura, Thrombocytopenic, Idiopathic
/
Platelet Transfusion
/
Dog Diseases
/
Antineoplastic Agents, Phytogenic
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2015
Type:
Article
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