Effect of CO2 laser assisted laryngoscope on glottic carcinoma / 中国医师杂志

ABSTRACT

Objective To prospectively investigate laryngoscopy-assisted CO2 laser in the treatment of glottic laryngeal carcinoma.Methods 97 patients with early glottic laryngeal carcinoma in our hospital were selected and divided into control group (n =48) and observation group (n =49) according to random number table.The control group was treated with partial laryngectomy and the observation group was treated with laryngoscopy-assisted CO2 laser.The clinical efficacy,serum level of α1-acid glycoprotein (α1-AG) and ceruloplasmin (CER) after 10 min of the surgery and changes of the indicators of voice function [fundamental frequency jitter (jitter),the longest sound time (MPT),sound pressure level (SPL)] were observed and compared between the two groups,and the incidence of complications and quality of life (QOL) scores were statistically compared.Results The total remission rate in the observation group was 79.59％ (39/49),which was higher than that in the control group 56.25％ (27/48),with statistically significant difference (x2 =6.075,P =0.014).The levels of serum α1-AG and CER in the observation group 10 min after surgery were lower than those in the control group,with statistically significant difference (t =2.641,P =0.010,t =31.242,P =0.000).From 2 weeks after surgery to 3 months after surgery,SPL and MPT of two groups decreased first and then increased;Jitter increased first and then decreased,and the changing amplitude in the observation group was smaller than that in the control group,with statistically significant difference (P ＜ 0.05).The incidence of complications in the observation group was 2.04％ (1/49),which was lower than that in the control group 16.67％ (8/48),with statistically significant difference (P ＜ 0.05);3 months after surgery,the QOL score of the observation group was higher than that of the control group,with statistically significant difference (P ＜ 0.05).Conclusions Supporting laryngoscope CO2 laser surgery can improve stress state and quality of life of early glottic laryngeal cancer patients,and the incidence of complications is low.It has little effect on voice function.