Observation on the correlation between chronic renal insufficiency and the Helicobacter Pylori infection in elderly patients and the relative clinical treatment effects / 中国医学装备

ABSTRACT

Objective:To investigate the correlation between chronic renal insufficiency (CRF) and helicobacter pylori (HP) infection in elderly patients and the relative clinical treatment effects.Methods:In this study, 150 elderly patients with CRF were selected as the observation group and 40 health individuals who were confirmed in the physical examination were selected as the control group.All of them underwent examination of 14C-urea breath test (UBT) so as to diagnose the HP infection rate.100 patients with CRF combined with HP infection in 150 elderly patients with CRF were divided into sequential treatment group (50 cases) and triple treatment group (50 cases) according to the random number table method.The two groups were implement sequential treatment and routine triple treatment, respectively, and the clinical effects of the two methods were evaluated after they were continuously treated 10 d.The clearance rate of HP and symptom score of the two methods were compared, and the safeties of the two methods were evaluated by the examining functions of liver and kidney.Results:The results of 14C-UBT showed that the HP infection rate was 72％ (108cases) in observation group, which was significantly higher than that (32.50％) in control group (x2=28.324, P<0.05) .The clearance rate of HP in sequential treatment group was 98.00％, which was significantly higher than that (88.00％) in triple treatment group, and the clinically effective rate in sequential treatment group was 94.00％, which was significantly higher than that (84.00％) in triple treatment group, and the differences of them was statistically significant (x2=4.231, x2=5.576, P<0.05) .The scores of abdominal distension, abdominal pain, belching and anorexia of sequential treatment group were significantly lower than those of triple treatment group after treatment (t=12.432, t=1.223, t=10.276, t=9.326, P<0.05) .Besides, the differences of indicators of liver and kidney function between sequential treatment group and triple treatment group after treatment were no significant (t=12.432, t=1.223, t=10.276, t=9.326, P<0.05) .Conclusion:The incidence rate of HP infection in elderly patients with CRF is significantly higher than those of healthy people.For patients with CRF, routine HP detection should be carried out, moreover, compared with triple treatment, sequential treatment holds a more effective and safe therapeutic outcome.