Evaluation of the serum apolipoprotein A1 and apolipoprotein B in cerebral vascular accident patients

ABSTRACT

Background: Levels of Apolipoprotein A1 (ApoA1) and Apolipoprotein B (ApoB) had changed more significantly than that of other serum lipids in patients with Cerebral Vascular Accident (CVA). Objectives: The study aims to determine the value of ApoA1 and ApoB contents and other serum lipid indices in a group of old people with CVA. Subjects and method: 40 healthy people at the age of over 60 years old and 40 patients with computer tomography-diagnosed CVA at the same age were involved in the study. Both groups were analysed for serum lipid indices, including total cholesterol, triglycerides, HDL-C, LDL-C, ApoA1 and ApoB levels. Results: There was no significant difference in serum lipid parameters such as total cholesterol, triglycerides, HDL-C; LDL-C levels and the total cholesterol/HDL-C ratio between the control and the case groups. The rate of ApoA1/Apo B changed most significantly, followed by ApoA1 and ApoB levels in the case group. The people having ApoA1 level less than 110mg/dl was 2.5 times more likely to have CVA. The people having apoB level more than 90mg/dl was 6.9 times more likely to have CVA. The people having apoA1/ApoB ratio less than 1.2 may be at risk of CVA 9.8 times higher than others. Conclusion: The reduction in ApoA1 level, the increase in apoB level and the decrease in ApoA1/ApoB ratio had statistic significance in the groups of patients with CVA.