Recent advance in the theoretical research and clinical application of 18F-FDG PET in assessment of epithelial-mesenchymal transition / 中华核医学与分子影像杂志

ABSTRACT

Epithelial-mesenchymal transition (EMT) is recognized as a central driver for many malignant tumor behaviors.Detection of EMT plays the pivotal role in early prediction of tumor metastasis and therapy resistance,as well as in evaluation of targeting EMT to reverse chemoresistance.Nowadays,the major way to distinguish EMT mainly depends on examination of molecular biomarkers of acquired tumor tissues or cells.18F-fluorodeoxyglucose (FDG) PET imaging,which reflects the glucose metabolism,has emerged as a potential method to diagnose and govern EMT.This review summarizes the recent advances in theoretical research and clinical application of 18F-FDG PET in assessment of EMT.