Research advances in pleiotropic effects of statins in elderly patients / 中华老年医学杂志

ABSTRACT

Statins are collectively referred to as hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitors.They exert powerful cholesterol-lowering effects by inhibiting key steps in the sterol biosynthetic pathway.At present,nearly 200 million people worldwide use statins.As clinical research progresses,the pleiotropic effects of statins are gradually discovered,especially those in the prevention and treatment of diseases of the circulatory system,nervous system and digestive system with high incidences in the elderly.We should to be alert to the adverse effects of statins and pay attention to the pleiotropic effects of statins in the elderly at the same time.