Role of primary cilia in common skin tumors / 中华皮肤科杂志

ABSTRACT

Primary cilium has attracted increasing attention in the biomedical field in recent years.It exists in the surface of various cells and is micro-sized,but its complex structures have not been clear.The primary cilium has an important role in sensory perception.Cells can receive extracellular mechanical and chemical signals through primary cilia,and primary cilia can assist in transferring signals into cells,followed by cellular responses.Recent studies have shown that the primary cilium also plays an important role in embryonic development and malignant transformation of cells.The investigation into primary cilia will facilitate the understanding of malignant transformation of cells and development of tumors.According to the related literature in recent years,this review summarizes the relationship between the primary cilium and common skin tumors,as well as potential targets for these tumors,so as to provide references and new sights for further researches.