Epidemiology of pathogens causing acute respiratory infections in children in Beijing during 2016 to 2018 / 中华微生物学和免疫学杂志

ABSTRACT

Objective To investigate the epidemiology of pathogens causing acute respiratory in-fections in children in Beijing from December 2016 to February 2018. Methods Clinical data of 34665 ca-ses of acute respiratory infections in Beijing Children's Hospital from December 2016 to February 2018 were reviewed. Indirect immunofluorescence antibody test ( IFAT) was performed to detect IgM antibodies against eight common respiratory pathogens including respiratory syncytial virus ( RSV) , influenza virus A ( IFA) , influenza virus B (IFB), parainfluenza virus (PIV), adenovirus (ADV),Mycoplasma pneumonia (MP), Chlamydia pneumonia (CP) and Legionella pneumophila (LP). SPSS19. 0 software was used for statistical analysis. Results In the 34665 cases, 50. 45％ children were infected with at least one kind of respiratory pathogen. There were 56. 11％ (10309/18372) in mild outpatient group and 44. 06％ (7179/16293) in severe inpatient group. IFB was the most prevalent pathogen with a positive rate of 36. 56％ and co-infection rate of 9. 78％. IFB and MP co-infection was more common. Most of RSV strains were detected in children under 1 year of age. The positive rates of IFA, IFB and PIV peaked in patients at ages of 4-5 years. The rates of ADV, MP, CP and LP infections increased with age. IFB, MP, IFA and RSV were more prevalent in winter and spring. Other pathogens caused sporadic cases throughout the year. There were significant differences in the detection rates of IgM antibodies against the eight respiratory pathogens between the mild and severe groups (P=0. 00). Conclusions This study analyzed the epidemiology of respiratory pathogens in Beijing from December 2016 to February 2018 through reviewing test results of IgM antibodies against eight common respiratory pathogens in children with acute respiratory infections. It might be conductive to the prevention of antimicrobial abuse and reduction of economic burden to families.