Progress of circular RNA in gastric cancer / 肿瘤研究与临床

ABSTRACT

With the progress of RNA research techniques, researchers found some different expressions of circular RNA in gastric cancer patients. They have important biological functions that can serve as a "sponge" adsorpting small RNA, can regulate process of alternative splicing and transcription, and can combined with proteins involved in regulating gene expression and mediating the function of protein. A fraction of circular RNA can encode proteins. The circular RNA plays an important regulatory role in tumor cells proliferation, apoptosis, and cycle, but research in gastric cancer is still in infancy. This article reviews the significance, features, biological functions and the role of circular RNA in gastric cancer.