Clinical significance of the expression of p53, p63 and p73 in nasal and paranasal sinus carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 919-921, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-746578
ABSTRACT
OBJECTIVE@#To study the clinical significance of the expression of p53, p63 and p73 protein and the correlation of p53 and p63 in nasal and paranasal sinus carcinoma (NPSC).@*METHOD@#The immunohistochemical technique was used to detect the expression of p53, p63 and p73 in 67 cases of NPSC, para-cancer tissues and non-cancer tissues.@*RESULT@#The positive rate of p53 and p63 protein in NPSC was significantly higher than that in park cancer tissues and non-cancer tissues (P0.05).@*CONCLUSION@#There are positive correlation between p53 and p63 protein in NPSC, and they may play an important role in the tumorgenesis of NPSC. The p73 may not be associated with tumorgenesis of NPSC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parasitology
/
Pathology
/
Transcription Factors
/
Paranasal Sinus Neoplasms
/
Nuclear Proteins
/
Carcinoma, Squamous Cell
/
Trans-Activators
/
Nose Neoplasms
/
Tumor Suppressor Protein p53
/
Tumor Suppressor Proteins
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2008
Type:
Article
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