Observation of ultrastructure and ECP expression in nasal polyps / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 787-797, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-746583
ABSTRACT
OBJECTIVE@#To observe the ultrastructural feature and ECP expression in nasal polyps, and aim to explore its role in the pathogenesis of CRSwNP.@*METHOD@#5 CRSwNP, 5 CRS and 5 control patients underwent sinus surgery were gathered to detect its ultrastructure and expression of ECP by in situ hybridization and electron microscopy technique.@*RESULT@#Under electron microscopy, the eosinophilic cells in CRSwNP group increased, its membrane was intact but fold, the feature of pseudopodium, degranulation and cavitation were all found. The expression level of ECP mRNA was up-regulated.@*CONCLUSION@#The findings suggest that eosinophilic infiltrate and ECP cytologic inflammation reactions may involve in the pathogenesis of CRSwNP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Microscopy, Electron
/
Case-Control Studies
/
Nasal Polyps
/
Eosinophil Cationic Protein
/
Eosinophils
/
Metabolism
/
Nasal Mucosa
Type of study:
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2008
Type:
Article
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