Stat3 antisense oligodeoxynucleotide induces apoptosis in laryngeal carcinoma cells by regulating apoptosis-related factors / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 155-157, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-746652
ABSTRACT
OBJECTIVE@#To study the mechanism of apoptosis in laryngeal carcinoma cell induced by Stat3 antisense oligodeoxynucleotide (ASODN).@*METHOD@#The designed Stat3 ASODN was transferred into laryngeal carcinoma Hep-2 cell by lipofection. Expression of Bcl-2, Bax and C-Myc were detected by Western blot and PCR.@*RESULT@#Western blot and PCR results demonstrated that Stat3 ASODN could significantly increased the expression of Bax and decreased the expression of Bcl-2 and C-Myc when the concentration of antisense oligodeoxynucleotide were heightened.@*CONCLUSION@#Stat3 ASODN participate in apoptosis by enhancing the expression of Bax and reducing the expression of Bcl-2 and C-Myc.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Gene Expression Regulation, Neoplastic
/
Proto-Oncogene Proteins c-myc
/
Apoptosis
/
Proto-Oncogene Proteins c-bcl-2
/
Oligodeoxyribonucleotides, Antisense
/
Cell Line, Tumor
/
STAT3 Transcription Factor
/
Bcl-2-Associated X Protein
/
Genetics
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2010
Type:
Article
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