Expression and clinical significance of Ang-2 and MMP-7 in laryngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 978-981, 2009.
Article
in Zh
| WPRIM
| ID: wpr-746660
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the expression and clinical significance of Ang-2 and MMP-7 protein in laryngeal carcinoma tissue.@*METHOD@#Immunohistochemical technique was used to detect the expression of Ang-2 and MMP-7 protein in 65 tissues of laryngeal carcinoma and 34 biopsies of adjacent non- cancerous tissue. The relationship between the expression of Ang-2 and MMP-7 and invasion, metastasis or prognosis in laryngeal carcinoma tissue was analyzed.@*RESULT@#The positive rates of Ang-2 and MMP-7 were significantly higher in laryngeal carcinoma tissue than those in adjacent non-cancerous tissue (P 0.05). While the expression of Ang-2 significantly differed between patients with different T stage and clinical stage (P 0.05). Cox regression analysis indicated that Ang-2 and MMP-7 expression were independent prognostic factors of laryngeal carcinoma.@*CONCLUSION@#Overexpression of Ang-2 and MMP-7 was observed in laryngeal carcinoma and they might be served as an objective indicator for biological behaviour and prognosis.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Prognosis
/
Carcinoma, Squamous Cell
/
Laryngeal Neoplasms
/
Matrix Metalloproteinase 7
/
Angiopoietin-2
/
Metabolism
/
Neoplasm Staging
Type of study:
Prognostic_studies
Limits:
Adult
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Aged
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Aged80
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Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2009
Type:
Article