Study on the expression of Eotaxin and the role of histamine in allergic rhinitis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 1086-1088, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-746666
ABSTRACT
OBJECTIVE@#To explore the expression of Eotaxin and the effect of histamine in allergic rhinitis model (AR), and aim to explore the pathogenesis of AR.@*METHOD@#The AR models were established by application of ovum albumin in rats. The expression of Eotaxin in nasal mucosa, serum and nasal cavity lavage fluid, were observed before and after treatment of histamine or its antagonist by immunochemistry, RT-PCR and ELISA technique.@*RESULT@#The expression of Eotaxin in nasal lavage fluid and nasal mucosa increased after treatment of histamine (P < 0.05). Contrarily, the expression of Eotaxin in nasal lavage fluid, nasal mucosa and serum decreased after treatment of the antagonist of histamine.@*CONCLUSION@#Both histamine and its receptor can involve in the pathogenesis of AR by affecting the expression of Eotaxin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Histamine
/
Rhinitis, Allergic, Perennial
/
Rhinitis, Allergic, Seasonal
/
Rats, Sprague-Dawley
/
Chemokine CCL11
/
Metabolism
/
Nasal Mucosa
Limits:
Animals
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2009
Type:
Article
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