The expression of oncogene c-myc and its role on human laryngeal cancer / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 1127-1129, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-746688
ABSTRACT
OBJECTIVE@#To detect the expression of oncogene c-myc and explore its role on human laryngeal cancer.@*METHOD@#The mRNA and of oncogene c-myc levels were detected in human laryngeal cancer tissues and laryngeal normal tissues by the means of real-time PCR and immunohistochemistry, respectively.@*RESULT@#Compared with normal laryngeal tissues, the mRNA and protein levels of oncogene c-myc were both upregulated in laryngeal cancer tissues of all differentiation degree (P<0.05). Moreover, the level of c-myc was inverse correlated with the differentiation degree in human laryngeal cancer tissues.@*CONCLUSION@#The oncogene c-myc is overexpressed in human laryngeal cancer tissues, and c-myc may play an important role in carcinogenesis and progression of human laryngeal cancer tissues. It may provide a new target for gene therapy of human laryngeal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Carcinoma, Squamous Cell
/
Laryngeal Neoplasms
/
Proto-Oncogene Proteins c-myc
/
Genetics
/
Metabolism
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2009
Type:
Article
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