The expression of E-cadherin and occludin in epithelium of chronic rhinosinositis and its significance / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To explore the expression and distribution of barrier molecules in epithelium of various types of chronic rhinosinusitis and its significance.@*METHOD@#There were four groups including control (13 samples), Eos-CRSwNP (10 samples), nonEos-CRSwNP (14 samples), CRSsNP (11 samples). The method of immunohistochemistry was used to detect the protein expression of E-cadherin and occludin in nasal mucosa.@*RESULT@#There was positive staining extensively distributed among cells in nasal mucosa. There was no significant difference in these groups. However, the occludin mainly located on the top of epithelial cells. In normal nasal mucosa, the positive expression was continuous, however, it was discontinuous both in CRSwNP and CRSsNP groups.@*CONCLUSION@#There was no E-cadherin loss in the progression of pathophysiology of chronic rhinosinusitis. But the loss of occludin may correlate to the dysfunction of epithelial barrier, which was beneficial for the pathogen invasion.