Research progress of acute kanamycin sulfate-induced deafness in guinea pig / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 478-480, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-746777
ABSTRACT
To present a summary of current knowledge regarding acute kanamycin sulfate-induced deafness in guinea pig, by reviewing the published literature. Animal model of acute deafness induced by a single dose of kanamycin sulfate in combination with ethacrynic acid or furosemide in guinea pig was usually used to investigate the mechanism of cochlear cell degeneration. There were different time sequences of cell degeneration of spiral ganglion cell and hair cell in different studies. The findings may result from different doses, order of two drugs administration or time point chosen. There remains scope for further research in chronic kanamycin-induced deafness, which more replicates the type of exposure to people than acute deafness.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Kanamycin
/
Spiral Ganglion
/
Cochlea
/
Deafness
/
Disease Models, Animal
/
Ethacrynic Acid
/
Guinea Pigs
/
Hair Cells, Auditory
/
Anti-Bacterial Agents
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2012
Type:
Article
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