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Relationship between vasculogenic mimicry and clinic pathological features in laryngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 2071-2075, 2015.
Article in Chinese | WPRIM | ID: wpr-746824
ABSTRACT
OBJECTIVE@#To investigate the presence of vasculogenic mimicry in laryngeal squamous cell carcino- ma and explore its clinical significance.@*METHOD@#The presence of vasculogenic mimicry and expression of endotheli- um-dependent vessel in 138 laryngeal squamous cell carcinomas cases were detected by the immunohistochemistry and tissue microarray. Metlab software was used to evaluate the relationship among vasculogenic mimicry, mi- crovessel density and clinic pathological parameters in laryngeal carcinoma.@*RESULT@#We found vasculogenic mimicry in 32 (26.23%) of 122 laryngeal carcinoma samples. The mean of microvessel density is 12.61 per high-power field. The vasculogenic mimicry and expression of endothelium-dependent vessel were not significantly related to patient age or gender, tumor location, pathology grade, T stage or N stage (P > 0.05). However, the vasculo- genic mimicry and the mean of microvessel density were a little higher in patients older than 60, with poorly differ- entiated and patients with N₁₋₃ stage. Vasculogenic mimicry was positively correlatedwith microvessel density (r = 0.1927, P < 0.05).@*CONCLUSION@#Vasculogenic mimicry can occur in laryngeal carcinoma. Moreover, vasculogenic mimicry may be associated with recurrence and metastasis in laryngeal carcinoma.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Endothelium, Vascular / Immunohistochemistry / Carcinoma, Squamous Cell / Laryngeal Neoplasms / Squamous Cell Carcinoma of Head and Neck / Head and Neck Neoplasms / Neoplasm Recurrence, Local / Neovascularization, Pathologic Limits: Humans Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Endothelium, Vascular / Immunohistochemistry / Carcinoma, Squamous Cell / Laryngeal Neoplasms / Squamous Cell Carcinoma of Head and Neck / Head and Neck Neoplasms / Neoplasm Recurrence, Local / Neovascularization, Pathologic Limits: Humans Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2015 Type: Article