Associations of JAK1 gene polymorphisms with allergic rhinitis in Chinese Han populations / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#The aim of this study was to investigate the association of JAK1 polymorphisms with allergic rhinitis in China Han population.@*METHOD@#A total of 450 patients with AR and 615 healthy subjects as control were genotyped for the presence of three single nucleotide polymorphisms using polymerase chain reaction restriction fragment length polymorphism (PGR-RFLP) analysis of DNA extracted from blood samples.@*RESULT@#All control subjects were in Hardy-Weinberg equilibrium, but high frequencies of JAK1 the homozygous rs310241 CC genotype were observed in AR patients compared to controls (P < 0.05). The results also revealed that there was no association between the rest of two investigated SNPs and AR.@*CONCLUSION@#Our results suggested that JAK1 gene rs310241 CC genotype was associated with patients with AR.