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Meta-analysis of The olfaction effectiveness of glucocorticoid in the management of chronic rhinosinusitis with nasal polyposis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 1868-1872, 2015.
Article in Chinese | WPRIM | ID: wpr-746907
ABSTRACT
OBJECTIVE@#To evaluate the effectiveness of glucocorticoid in the management of olfaction in patients with chronic rhinosinusitis accompanied with nasal polyposis.@*METHOD@#The published studies of the effectiveness of glucocorticoid in the management of chronic rhinosinusitis with nasal polyposis were searched in the Medline, Cochrane, EMBASE, Springer and CNKI databases(from the date of establishment of the databases to December 2014). The trails selection based on inclusion criteria and the quality of the included studies was assessed and meta-analysis was performed with RevMan 5. 3 software.@*RESULT@#A total of 5 trials involving 325 patients were included. The Meta-analysis showed that oral glucocorticoid showed more significant improvement in subjective olfaction scores compared to placebo [SMD = -2.22, 95% CI (-3.94 - -0. 49), P 0.05], [SMD = 0.28, 95% CI (-0.08-0.64) P > 0.05].@*CONCLUSION@#According to current evidence, oral glucocorticoid can significantly improve subjective and objective olfaction among patients with CRSwNP, but nasal glucocorticoid cannot improve subjective or objective olfaction dysfunction.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Sinusitis / Smell / Nasal Polyps / Chronic Disease / Clinical Trials as Topic / Therapeutic Uses / Drug Therapy / Glucocorticoids Type of study: Controlled clinical trial / Systematic reviews Limits: Humans Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sinusitis / Smell / Nasal Polyps / Chronic Disease / Clinical Trials as Topic / Therapeutic Uses / Drug Therapy / Glucocorticoids Type of study: Controlled clinical trial / Systematic reviews Limits: Humans Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2015 Type: Article