Transforming Growth Factor-beta Levels in Human Aqueous Humor of Glaucomatous, Diabetic and Uveitic Eyes
Korean Journal of Ophthalmology
;
: 162-165, 2006.
Article
in English
| WPRIM
| ID: wpr-74698
ABSTRACT
PURPOSE:
Transforming growth factor-beta2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in uveitis-related secondary glaucoma. We investigated total TGF-beta2 levels and levels of the active form of TGF-beta2 in the aqueous humor of eyes with different types of glaucoma.METHODS:
The concentration of the total and active form of TGF-beta2 was measured in 63 patients with primary open angle glaucoma, neovascular glaucoma complicated with diabetes (NVG), and secondary open angle glaucoma complicated with uveitis (SOAG) using a double antibody 'sandwich-indirect' ELISA method.RESULTS:
The levels of total TGF-beta2 in the aqueous samples of POAG, NVG, and SOAG were elevated. The levels of active TGF-beta2 in the aqueous samples of POAG, and NVG were also elevated, whereas the level of active TGF-beta2 was within the normal range in the aqueous samples of SOAG.CONCLUSIONS:
These results suggest that the level of TGF-beta2 may play a role in the pathology of various types of glaucoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aqueous Humor
/
Uveitis
/
Severity of Illness Index
/
Enzyme-Linked Immunosorbent Assay
/
Biomarkers
/
Glaucoma, Angle-Closure
/
Glaucoma, Open-Angle
/
Transforming Growth Factor beta
/
Diabetic Retinopathy
Limits:
Adult
/
Aged
/
Aged80
/
Humans
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
2006
Type:
Article
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