Osteogenesis Imperfecta in Pregnancy: A Case Report / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 2276-2282, 2003.
Article
in Korean
| WPRIM
| ID: wpr-7470
ABSTRACT
Osteogenesis imperfecta (OI) is an inherited disease of connective tissue disorder which represents a phenotypically heterogeneous group of conditions that results from a number of genetic defects in the synthesis of type I collagen. A pregnancy associated with osteogenesis imperfecta is considered a high risk pregnancy because the disease is associated with various metabolic and hematologic disorders, as well as well-recongnized skeletal abnormalities. In addition to the mother with OI, the offspring has about a 25% to 50% chance of being affected, therefore genetic counseling before conception and prenatal diagnosis should be offered to all affected mothers. Patients with OI present a series of problems and require a multidisciplinary approach in their management. We present a case of parturient with osteogenesis imperfecta with brief review of literature.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Osteogenesis Imperfecta
/
Prenatal Diagnosis
/
Pregnancy, High-Risk
/
Connective Tissue
/
Collagen Type I
/
Heredity
/
Fertilization
/
Genetic Counseling
/
Mothers
Type of study:
Diagnostic study
Limits:
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2003
Type:
Article
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