Effect of p53 gene therapy on the local immunity and the efficacy of patients with nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 980-983, 2012.
Article
in Zh
| WPRIM
| ID: wpr-747009
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the tumor regression and local immune function in nasopharyngeal carcinoma patients treated with p53 gene therapy.@*METHOD@#The two-step immunohistochemical was done to detect the expression of tumor-infiltrating lymphocytes (TIL) T-cell receptor-CD3, CD4, CD8 and B cell receptor-CD20 in the primary tumor tissue of nasopharyngeal carcinoma. Nasal endoscopy with MRI or CT was used for evaluation of tumor size.@*RESULT@#The expression of CD3, CD4, CD8 was significantly increased after p53 gene treatment (P 0.05). In conventional treatment group, CD3, CD4, CD8 and CD20 (P > 0.05) did not show any significant difference. In gene therapy group at 3 months after treatment, 20 patients had achieved CR, 10 PR, 1 SD, 1 PD. In conventional treatment group, 11 patients had achieved CR, 12 PR,5 SD,3 PD. The response rate between treatment group and control group (CR+PR) was different (P < 0.05). CD3 and CD4 expression was correlated with tumor regression rate (P < 0.05, P < 0.01), and CD8 expression was correlated with the CR rate (P < 0.05).@*CONCLUSION@#T cells are the most proliferative cell of TII. in NPC patients after p53 gene therapy The local cellular immune status is positively correlated with tumor regression rate.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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Therapeutics
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Carcinoma
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Genetic Therapy
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CD4-Positive T-Lymphocytes
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Nasopharyngeal Neoplasms
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Genes, p53
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Lymphocytes, Tumor-Infiltrating
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Lymphocyte Count
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Allergy and Immunology
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2012
Type:
Article