The expression and clinical significance of hyaluronan synthase in nasal polyps / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To study the expression of hyaluronan synthasel-3 (HAS1-3) in nasal polyps, and discuss their clinical significance.@*METHOD@#The expression of HA, HAS1, HAS2 and HAS3 in nasal polyps group (25 cases) and inferior turbinate group (15 cases) was detected by immunohistochemistry and semi-quantitative RT-PCR.@*RESULT@#Compared with the control, the expression of HA, HAS1 and HAS3 was higher in nasal polyps (P0. 05).@*CONCLUSION@#The increase of HASI and HAS3 expression may be the main cause of the excessive deposition of HA in nasal polyps, which may play an important role in the pathogenic process of nasal polyps, and become a potential target for therapy of nasal polyps.