Expression of Th17 related cell factors and its significance in CRSsNP / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 946-948, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-747339
ABSTRACT
OBJECTIVE@#To detect the expression of Th17 nuclear factor RORC and cytokines IL-17A and IL-22 and neutrophil marker MPO and their correlations with CRSsNP.@*METHOD@#RT-PCR was used to detect mRNA expression of RORC, IL-17A and IL-22. Immunohistochemistry was used to assess the IL-17A positive cells in CRSsNP and control. ELISA was used to detect the expression of MPO.@*RESULT@#CRSsNP had higher mRNA expression of RORC, IL-17A and IL-22 and increased protein expression of MPO. The mRNA expression of RORC, IL-17A and IL-22 was positively correlated with each other but none of them was correlated with the expression of MPO in CRSsNP and control.@*CONCLUSION@#Both Th17 and neutrophils contribute to the pathogenesis of CRSsNP, however, the neutrophil infiltration may not be recruited by Th17 cytokines.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sinusitis
/
Chronic Disease
/
Interleukins
/
Interleukin-17
/
Neutrophil Infiltration
/
Allergy and Immunology
/
Nuclear Receptor Subfamily 1, Group F, Member 3
/
Th17 Cells
/
Neutrophils
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2012
Type:
Article
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