Effects of tripterine on NF-kappaB and eotaxin in nasal mucosa of allergic rhinitis rat / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To investigate the relationship among the expressions of NF-kappaB, Eotaxin and the effects of tripterine in nasal mucosa of allergic rhinitis rat and to discuss the possible mechanism of tripterine on allergic rhinitis.@*METHOD@#Forty healthy SD rats were randomly divided into four groups OVA group,tripterine group (T group), DM group, and SC group. Allergic rhinitis model was established by OVA. The pathological changes were observed by HE staining. The expressions of NF-kappaB and Eotaxin were examined by SP immunohistochemical analysis.@*RESULT@#There was no pathological change in SC group. Nasal mucosa in T and DM group was swelling,and there were some inflammatory cells. Nasal mucosa in OVA group was highly swelling, and there were abundant inflammatory cells. NF-kappaB and Eotaxin expression in OVA group was significantly different from the other three groups (P0.05). The expression of NF-kappaB in OVA group had positive correlation with the expression of Eotaxin (r=0.908, P<0.01).@*CONCLUSION@#Tripterine can inhibit expression of Eotaxin by restraining the activation of NF-kappaB.