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The analysis of the calcification in differentiating malignant thyroid neoplasm and the molecular mechanisms for the formation of the calcification / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 763-766, 2012.
Article in Chinese | WPRIM | ID: wpr-747383
ABSTRACT
The purpose of this review is to investigate the value of the calcification in differentiating malignant thyroid neoplasm and the molecular mechanisms for the formation of the calcification. Many published reports have proved the presence of calcifications in thyroid neoplasm and calcified nodules in these studies are more frequently malignant than noncalcified nodules. Through viewing the related references, we found that psammoma bodies (PBs), Runx2, osteocalcin, osteopontin, CD44v6 play an important role in the molecular mechanisms in the formation of the calcification in PTC. But further study is required for elucidating the mode of action.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Calcinosis / Thyroid Neoplasms / Osteocalcin / Thyroid Nodule / Hyaluronan Receptors / Diagnosis / Core Binding Factor Alpha 1 Subunit / Osteopontin / Metabolism Type of study: Diagnostic study Limits: Humans Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Calcinosis / Thyroid Neoplasms / Osteocalcin / Thyroid Nodule / Hyaluronan Receptors / Diagnosis / Core Binding Factor Alpha 1 Subunit / Osteopontin / Metabolism Type of study: Diagnostic study Limits: Humans Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2012 Type: Article