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Expression of C-erbB-2 and EGFR expression and its relationship with cell proliferation in nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 67-70, 2011.
Article in Chinese | WPRIM | ID: wpr-747425
ABSTRACT
OBJECTIVE@#To study the expression of epidermal growth factor receptor (EGFR), C-erbB-2 and its relationship with cell proliferation in nasopharyngeal carcinoma.@*METHOD@#Expression of C-erbB-2, EGFR and proliferating cell nuclear antigen (PCNA) were detected with immunohistochemical staining in 32 nasopharyngeal carcinoma samples and 12 chronic inflammatory nasopharyngeal tissue samples.@*RESULT@#The positive rate of EGFR,C-erbB-2, and PCNA expression in nasopharyngeal carcinoma was 65.6%, 37.5%, and (42.5 +/- 22.6)%, respectively, which was significantly higher than that in chronic inflammatory nasopharyngeal tissue (P < 0.05). There were positive correlations between the positive rate of EGFR, C-erbB-2, and PCNA expression and histopathological stage. The co-expression of C-erbB2 and EGFR was found in 62.5% (20/32) nasopharyngeal carcinoma samples. There was a positive correlation between C-erbB-2 and EGFR expression (r = 0.38, P < 0.05). The highest percentage of PCNA expression was found in carcinoma samples with co-expression of C-erbB and EGFR.@*CONCLUSION@#C-erbB-2, EGFR might have synergetic effect in the development and progress of nasopharyngeal carcinoma. The co-expression of C-erbB-2 and EGFR closely correlates with cell proliferation status.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Carcinoma, Squamous Cell / Nasopharyngeal Neoplasms / Receptor, ErbB-2 / Proliferating Cell Nuclear Antigen / Respiratory Mucosa / Cell Proliferation / ErbB Receptors / Metabolism Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Carcinoma, Squamous Cell / Nasopharyngeal Neoplasms / Receptor, ErbB-2 / Proliferating Cell Nuclear Antigen / Respiratory Mucosa / Cell Proliferation / ErbB Receptors / Metabolism Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2011 Type: Article