Study on the correlation of IgE and GM-CSF contents with eosinophil accumulation in nasal polyp / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 916-918, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-747613
ABSTRACT
OBJECTIVE@#To study the effect of IgE, GM-CSF on eosinophil accumulation in the nasal polyps and find the relationship between them.@*METHOD@#Thirty mucosa constitution samples of nasal polyps and eleven inferior nasal concha were observed. The distribution of IgE was detected by SP immunohistochemical method, while the concentration of GM-CSF was measured by ELISA technique and the number of eosinophils were counted in the same tissues.@*RESULT@#The level of IgE, GM-CSF and eosinophils had significant different between the nasal polyps and control group (P < 0.01). There was positive correlation between IgE/GM-CSF and the number of eosinophils in the nasal polyps group (r = 0.65, 0.62, P < 0.01). The correlation between concentration of IgE and GM-CSF was also significant in nasal polyps group (r = 0.52, P < 0.01).@*CONCLUSION@#Nasal polyps is characterized by eosinophil accumulation. IgE and GM-CSF may contribute to the recruitment of eosinophils in nasal polyps. Type-I allergy mediated by IgE play an important role in the pathogenesis of nasal polyps.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Immunoglobulin E
/
Nasal Polyps
/
Granulocyte-Macrophage Colony-Stimulating Factor
/
Eosinophils
/
Metabolism
/
Nasal Mucosa
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2007
Type:
Article
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