Expression and significance of DNA-dependent protein kinase in human laryngeal squamous cell carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 1641-1644, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-747675
ABSTRACT
OBJECTIVE@#To study the expression of DNA-dependent protein kinase (DNA-PK) in human laryngeal squamous cell carcinoma (LSCC) and normal laryngeal mucosa (NLM), and to analysize the relationship between the expression and the clinicopathologic parameters of LSCC.@*METHOD@#Immunohistochemical technique (Envision) was used to detect the expression of DNA-PK in 64 cases of LSCC and 15 cases of NLM. To investigate an investigation was conducted on the relationship between the expression and clinico-pathological features of LSCC.@*RESULT@#DNA-PK was lowly expressed in NLM and highly expressed in LSCC,the positive rate of DNA-PK expression was 26.67% (4/15), 78.13% (50/64), respectively, and there was significant different difference between the two groups (P 0.05).@*CONCLUSION@#DNA-PK may be involved in disease development of LSCC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Carcinoma, Squamous Cell
/
Laryngeal Neoplasms
/
DNA-Activated Protein Kinase
/
Squamous Cell Carcinoma of Head and Neck
/
Head and Neck Neoplasms
/
Laryngeal Mucosa
/
Larynx
/
Lymph Nodes
/
Lymphatic Metastasis
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2014
Type:
Article
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