Distribution change of mast cells in human nasal polyps / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 1337-1340, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-747689
ABSTRACT
OBJECTIVE@#To investigate the distribution of mast cells in nasal polyps.@*METHOD@#Biopsy specimens from patients with nasal polyps (n = 20) and control patients (n = 8) were obtained and included in this study. The distribution of mast cells in nasal polyps and the expression of chemokines (CCL5, CCL11, CX3CL1, IL-8, IL-6) in the epithelial cells of normal nasal mucosa and nasal polyps was determined by immunohistochemistry.@*RESULT@#Mast cells migrate to intraepithelial in nasal polyps and the expression of chemokines (CCL5, CCL11, CX3CL1, IL-8) was up regulated in the epithelial cells of nasal polyps compare to normal nasal mucosa.@*CONCLUSION@#Our findings showed that mast cells migrate to intraepithelial in nasal polyps and the over expression of chemotaxins (CCL5, CCL11, CX3CL1, IL-8) may be response for mast cells' migration in nasal polyps. Mast cells might be associated with the development of nasal polyps.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Immunohistochemistry
/
Up-Regulation
/
Nasal Polyps
/
Interleukin-8
/
Interleukin-6
/
Chemokine CCL5
/
Cell Biology
/
Epithelial Cells
/
Chemokine CCL11
Limits:
Humans
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2014
Type:
Article
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