Effect evaluation of allergen specific immunotherapy in patients with allergic rhinitis and asthma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 629-632, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-747747
ABSTRACT
OBJECTIVE@#To evaluate the effect of allergen specific immunotherapy (SIT) in patients with allergic rhinitis and asthma. METHOD A total of 68 patients with allergic rhinitis and asthma sensitized to dust mite were recruited into the study. They were randomly divided into two groups SIT group n = 34 and symptomatic therapy (ST) group n = 34. Patients in ST group received medication to treat, the symptoms, patients in SIT group received medication and 3 years of standardized allergen vaccine therapy. Evaluation index of therapy includes rhinitis symptoms score, asthma symptoms score, drug score, skin prick test, serum specificity IgE (sIgE) , peripheral eosinophil (Eos) counting, lung function. The new sensitinogen rate was also assessed.@*RESULT@#Clinical symptom scores, drug scores, lung function, blood eosinophil numbers and skin test result were all improved significantly after 3-year treatment in SIT group compared to those in ST group (P < 0.01). Although the level of serum slgE was decreased,there exited no statistic diferences between two groups. Only 8.8% patients have the new sensitization in SIT group, and 52.9% in ST group. There were no serious adverse reactions in treatment process.@*CONCLUSION@#SIT for patients with AR and asthma can obtain excellent clinical efficacy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Blood
/
Immunoglobulin E
/
Skin Tests
/
Sensitivity and Specificity
/
Desensitization, Immunologic
/
Pyroglyphidae
/
Drug Therapy
/
Eosinophils
/
Rhinitis, Allergic
Type of study:
Diagnostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS