Expression and significance of C/EBPα and CK10 in nasal inverted papilloma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 437-440, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-747801
ABSTRACT
OBJECTIVE@#The expression of C/EBPα, CK10 in nasal inverted papilloma (NIP) were detected in the study. Further discussed their significance in genesia, development and recurrence of NIP.@*METHOD@#Three groups including nasal cavity mucosae (NM 10 cases), nasal polyp (NP 20 cases) and NIP (30 cases) were selected in the study. Expretion of C/EBPα, CK10 were detected by immunohistochemisty PV-6000 method.@*RESULT@#(1) The different expression of C/EBPα and CK10 in the group of NM, NP and NIP was statistically significant (P < 0.05). (2) The different expression of C/EBPα, CK10 in the group of benign NIP and NIP with atypical hyperplasia was statistically significant (P < 0.05). (3) The different expression of C/EBPα and CK10 in the group of NIP with recurrence and NIP with no recurrence was statistically significant, P < 0.05, respectively. (4) Our result indicate that the relationship of C/EBPα and CK10 (r = 0.578, P < 0.01) was direct correlation. The difference was statistically significant.@*CONCLUSION@#In conclusion, the present results describe C/EBPα, CK10 expression in NIP and their possible implication in the regulation of tumor growth and differentiation. C/EBPα and CK10 production may prove useful in terms of a prognostic marker for the recurrence in nasal inverted papilloma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Nasal Polyps
/
Nose
/
Nose Neoplasms
/
Papilloma, Inverted
/
CCAAT-Enhancer-Binding Proteins
/
Keratin-10
/
Genetics
/
Metabolism
/
Neoplasm Recurrence, Local
Limits:
Humans
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2015
Type:
Article
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