Radiation injury of interstitial implantation 125I seeds on normal trachea tissue of rabbits / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To study the radition injury of tracheal mucous membrane tissue after interstitial implanted radioactive 125I in normal rabbit,improve the safety of clinical application.@*METHOD@#Sixty New Zealand rabbits, weighing 2.15-2.30 kg, were randomly divided into 1 w, 1 m, 2 m, 4 m and the control group, the control group was further divided into four subgroups. The 0.8mCi 125I seeds were implanted into the tissue by the first tracheal ring in the treatment groups and nonradioactive seeds were implanted in the control group. Taking the tracheal mucous membrane tissue for pathological examination by HE staining to observe the mucosal injury and VEGF, Pan-Cadherin immunohistochemical staining to observe the expression in differernt time.@*RESULT@#Immunohistochemical staining VEGF and Pan-Cadherin have statistically significant differences in the expression on different time, the expression is dynamic.@*CONCLUSION@#The expression of VEGF and Pan-Cadherin reflect the radioactive 125I seed has little influence on normal trachea tissue and the damage can be repaired by the regeneration of the basal cell.