Expression of PCNA, BCL-2, CD4+, CD8+ in the adenoid tissues from children with secretory otitis media / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 740-742, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-747918
ABSTRACT
OBJECTIVE@#To investigate the relationship between immune status of adenoids and secretory otitis media (SOM).@*METHOD@#The adenoid tissue samples of 72 cases with SOM and 30 cases with adenoid hypertrophy without SOM were studied by immunohistochemical method.@*RESULT@#The PCNA, BCL-2, CD4+, CD8+ and CD4+ / CD8+ in SOM tissue samples were 30.85 +/- 1.73, 21.27 +/- 1.25, 41.90 +/- 9.07, 20.45 +/- 7.08 and 2.10 +/- 0.17, respectively, which were much more than that of tissue samples without SOM (25.25 +/- 1.75, 14.05 +/- 1.02, 16.30 +/- 8.21, 11.15 +/- 5.71, 1.39 +/- 0.15 respectively) (P < 0.01). The expression of CD4+ in T-lymphocyte was obviously higher than that of CD8+.@*CONCLUSION@#In adenoid tissues of SOM patients, the activity of T-lymphocyte subsets are increased,the adenoids are enlarged and local immunity are enhanced. Therefore,adenoidectomy should be applied in SOM patients as early as possible.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Otitis Media with Effusion
/
CD4-Positive T-Lymphocytes
/
Adenoids
/
Proliferating Cell Nuclear Antigen
/
CD8-Positive T-Lymphocytes
/
Proto-Oncogene Proteins c-bcl-2
/
Allergy and Immunology
/
Metabolism
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2010
Type:
Article
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