Expression of SSTR2 and P-STAT3 in human olfactory neuroblastoma / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To detect the expression and relationship between somatostatin receptor 2 (SSTR2) and phosphorylated STAT3 (P-STAT3) in human olfactory neuroblastoma (ONB) and adjacent normal olfactory nerve tissue.@*METHOD@#Immunohistochemical (IHC) staining was used to detect the expression of SSTR2 and P-STAT3 in tumor and adjacent normal olfactory nerve tissue from 11 ONB patients.@*RESULT@#SSTR2 was mainly expressed in cell cytoplasm and the expression intensity was significantly stronger in tumor tissues than in adjacent normal tissues (P<0.01). P-STAT3 was mainly expressed in cell nuclear in tumor tissues. No expression was found in adjacent normal tissues. There was a negative correlation between the expression intensity of SSTR2 and P-STAT3 (r(s) = -0.367, P<0.05).@*CONCLUSION@#Lower expression of SSTR2 and activation of STAT3 in ONB cells might contribute to the development of ONB.