Expressions of LL-37 and IL-8 in chronic sinusitis with nasal polyps / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 337-340, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-748004
ABSTRACT
OBJECTIVE@#To investigate the expressions of LL-37 and IL-8 in chronic sinusitis with nasal polyps.@*METHOD@#Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical staining were used to detect the expressions of LL-37 and IL-8 in nasal polyp tissues of 31 patients with chronic sinusitis and inferior turbinate tissues of 11 patients with chronic rhinitis.@*RESULT@#LL-37 and IL-8 mRNA were all positively expressed in all nasal polyps and inferior turbinate tissues. There were significant increases of LL-37 and IL-8 mRNA expressions in nasal polyps compared with the inferior turbinate tissues (P < 0.01). There were also significant increases of positive expression rates of LL-37 and IL-8 protein in nasal polyps, compared with the inferior turbinate tissues (P < 0.01). There was a positive relationship between the mRNA and protein expressions of LL37 and IL-8 (P < 0.01).@*CONCLUSION@#The expressions of LL-37 and IL-8 in nasal polyps suggest that they may play a role in the pathogenesis of chronic sinusitis. Besides its innate immune, LL-37 could enhance human body's anti-infected function by increasing acquired immune.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sinusitis
/
Nasal Polyps
/
Chronic Disease
/
Interleukin-8
/
Antimicrobial Cationic Peptides
/
Cathelicidins
/
Metabolism
/
Nasal Mucosa
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2010
Type:
Article
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