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The expression and significance of IGF-1R in nasal polyp and its relationship with allergic rhinitis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 1019-1024, 2011.
Article in Chinese | WPRIM | ID: wpr-748030
ABSTRACT
OBJECTIVE@#To study the expression of insulin-like growth factor-1 receptor(IGF-1R) in nasal polyps and its relationship with allergic rhinitis.@*METHOD@#The mRNA and protein expression of IGF-1R in 40 cases (20 cases with allergic rhinitis and 20 cases without) nasal polyps tissue (the CRSWNP group) and 20 middle turbinate tissue samples (the control group) were examined by fluorescence quantitative polymerase chain reaction (FQ-PCR) and immunohistochemistry.@*RESULT@#The positive staining rate of IGF-1R protein of nasal polyps tissue is 70.8% and that of control is 12.3%, the expression of IGF-1R mRNA of nasal polyp is 0.748 +/- 0.111,which is significant higher than that of the control group is 0.107 +/- 0.208 (P < 0.01). No significant difference of the expression of IGF-1R mRNA between with and without allergic rhinitis cases and between with and without endoscopy sinus surgery history cases in the CRSWNP group.@*CONCLUSION@#The overexpression of IGF-1R maybe play important roles in the formation of nasal polyp. Hypersensitivity reaction type I mediated by IgE has no contribution to the overexpression of the IGF-1R.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / RNA, Messenger / Case-Control Studies / Nasal Polyps / Receptor, IGF Type 1 / Allergy and Immunology / Genetics / Hypersensitivity / Metabolism Type of study: Observational study Limits: Adult / Female / Humans / Male Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / RNA, Messenger / Case-Control Studies / Nasal Polyps / Receptor, IGF Type 1 / Allergy and Immunology / Genetics / Hypersensitivity / Metabolism Type of study: Observational study Limits: Adult / Female / Humans / Male Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2011 Type: Article