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Up-regulation of MUC2 mucin gene in chronic rhinosinusitis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 486-488, 2007.
Article in Chinese | WPRIM | ID: wpr-748390
ABSTRACT
OBJECTIVE@#To investigate the expression of MUC2 in human sinus mucosa and compare the expression of MUC2 mRNAs in normal and in chronic sinus mucosa.@*METHOD@#Thirty-two chronic ethmoid sinusitis mucosa samples and 8 normal ethmoid sinus mucosa samples were obtained; RNAs were extracted from sinus mucosa, and fluorescent quantitative PCR was performed for MUC2.@*RESULT@#The levels of MUC2 mRNAs in chronic rhinosinusitis were significantly increased compared with those in normal sinus mucosa.@*CONCLUSION@#This result suggest that up-regulation of MUC2 in chronic rhinosinusitis may play an important role in the pathogenesis of sinus hypersecretion in chronic rhinosinusitis.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Sinusitis / Case-Control Studies / Up-Regulation / Mucin-2 / Genetics / Metabolism / Nasal Mucosa Type of study: Observational study Limits: Adult / Female / Humans / Male Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Sinusitis / Case-Control Studies / Up-Regulation / Mucin-2 / Genetics / Metabolism / Nasal Mucosa Type of study: Observational study Limits: Adult / Female / Humans / Male Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2007 Type: Article