Expression of microtubule-associated protein 1 light chain 3 in laryngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 497-500, 2011.
Article
in Zh
| WPRIM
| ID: wpr-748434
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the expression of microtuble-associated protein 1 light chain 3 (LC3) in laryngeal squamous cell carcinoma (LSCC).@*METHOD@#The expression of LC3 in 50 cases of LSCC, 45 cases of para-carcinoma, 10 cases of laryngeal papilloma and 16 cases of polyp of vocal cord were detected by immunohistochemistry (MaxVision method). Expression level of LC3 mRNA was assayed by RT-PCR in 41 of LSCC, 41 of para-carcinoma tissue and 11 of polyp of vocal cord.@*RESULT@#The positive rates of LC3 protein expression were 60.0%, 93.3%, 90.0%, 93.8% in LSCC tissue, para-carcinoma, laryngeal papilloma and poly of vocal card tissues, respectively. The positive rates of LC3 were significantly lower in LSCC than in para-carcinoma and poly of vocal cord (chi2 = 18.135, P 0.05).@*CONCLUSION@#Expression of LC3 are down-regulated in LSCC. The change of autophagic capacity may play an important role in occurrence and development of LSCC.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Carcinoma, Squamous Cell
/
Laryngeal Neoplasms
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Genetics
/
Lymphatic Metastasis
/
Metabolism
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Microtubule-Associated Proteins
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Neoplasm Staging
Limits:
Aged
/
Aged80
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Female
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Humans
/
Male
Language:
Zh
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2011
Type:
Article