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RAGE, NF-kappaB, p21 expressions in mouse spiral ganglion cells / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 265-268, 2014.
Article in Chinese | WPRIM | ID: wpr-748529
ABSTRACT
OBJECTIVE@#To research advanced glycation end-product receptors (RAGE), NF-kappaB, p21 expressions in C57BL/6j mice cochlea spiral ganglion cells(SGC) ,and then to investigate the presbycusis pathogenesis.@*METHOD@#To take C57BL/6J mice2 month 25,and 10 month 25. Histological sections were observed the SGC. RAGE, NF-kappaB, p21 were immunohistochemical in the SGC,with IPP6 to IOD.@*RESULT@#(1) The count SGCs of 10 month-old was obviously decreased comparing to 2 month-old, the count of 2 month SGC is 39 +/- 5, 10 month group is 20 +/- 6, P < 0.01; (2) RAGE, NF-kappaB, p21 expressed in spiral ganglion cell,different place with different age,and the means optical density in the 10 month are higher than the 2 month, respectively. The IOD of RAGE expression in 2 month SGC 0.179 +/- 0.025, 10 month IOD 0.308 +/- 0.050; The IOD of NF-kappaB expression in 2 month SGC 0.181 +/- 0.045, 10 month IOD 0.335 +/- 0.120; The IOD of p21 expression in 2 month SGC 0.160 +/- 0.023, 10 month IOD 0.365 +/- 0.031, compare with 2 group, respectively, P < 0.05, and the difference has statistics sense.@*CONCLUSION@#RAGE,NF-kappaB, p21 expressions are in SGCs and increases with the aging of SGCs, suppose RAGE, NF-kappaB, p21 may participate in the process of presbycusis pathogenesis.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Presbycusis / Aging / Receptors, Immunologic / Spiral Ganglion / NF-kappa B / Proto-Oncogene Proteins p21(ras) / Receptor for Advanced Glycation End Products / Metabolism / Mice, Inbred C57BL Limits: Animals Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Presbycusis / Aging / Receptors, Immunologic / Spiral Ganglion / NF-kappa B / Proto-Oncogene Proteins p21(ras) / Receptor for Advanced Glycation End Products / Metabolism / Mice, Inbred C57BL Limits: Animals Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2014 Type: Article