A Case of 5-Fluorouracil Induced Encephalopathy / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 118-120, 2010.
Article
in English
| WPRIM
| ID: wpr-74856
ABSTRACT
Patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at risk for experiencing serious adverse effects following 5-fluorouracil (5-FU) based chemotherapy. Neurotoxicity is considered an extremely rare side effect of 5-FU. We report here on an unusual case of 5-FU induced encephalopathy. A 38-year-old woman with advanced gastric carcinoma was treated with adjuvant chemotherapy that consisted of infused 5-FU (1,000 mg/m2) for 5 days and cisplatin (60 mg/m2) on day 1 following total gastrectomy. Nineteen days after starting chemotherapy, the patient displayed a sudden onset of slurred speech, confusion, cognitive disturbances and paranoia. A magnetic resonance image (MRI) of the brain showed no structural abnormalities, and the other laboratory tests provided no explanations for her symptoms, other than a slightly elevated ammonia level. The patient was treated with a lactulose retention enema and thiamine infusion, the 5-FU was halted and her symptoms then recovered after 7 days.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paranoid Disorders
/
Retention, Psychology
/
Thiamine
/
Brain
/
Magnetic Resonance Spectroscopy
/
Cisplatin
/
Chemotherapy, Adjuvant
/
Dihydrouracil Dehydrogenase (NADP)
/
Enema
/
Fluorouracil
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Cancer Research and Treatment
Year:
2010
Type:
Article
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