Expression of thymic stromal lymphopoietin in nasal mucosa of a mouse model with allergic rhinitis / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 794-799, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-748651
ABSTRACT
OBJECTIVE@#To investigate the expression of thymic stromal lymphopoietin (TSLP) in the nasal mucosa of mouse with allergic rhinitis.@*METHOD@#Twenty wide type BALB/c mouse were divided into 2 groups randomly. Two groups were included, allergic rhinitis group (group A) and control group (group B). The mouse model of allergic rhinitis was established by ovalbumin (OVA) sensitization and challenge. The expressions of TSLP in the nasal mucosa was determined by realtime quantitative PCR and immunohistochemical method.@*RESULT@#The expression of TSLP in the nasal mucosa of group A was significantly higher than that in group B (P<0.01).@*CONCLUSION@#TSLP plays a role in the mouse model of allergic rhinitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovalbumin
/
Rhinitis, Allergic, Perennial
/
Cytokines
/
Disease Models, Animal
/
Metabolism
/
Mice, Inbred BALB C
/
Nasal Mucosa
Limits:
Animals
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2009
Type:
Article
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