The relationship between the expression of EGFR NF-kappaB and radiosensitivity in human nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 678-681, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-748668
ABSTRACT
OBJECTIVE@#To detect the expression of EGFR and NF-kappaB and the relationship between the two factors and radiosensitivity in human nasopharyngeal carcinoma.@*METHOD@#The expression of EGFR and NF-kappaB were detected with immunohistochemical staining SP methods in forty-one patients. The radiotherapy effect was assessed by follow up visit and clinical judgement. All of the forty-one patients were divided into three groups the complete response group, the partial response (or the stable disease) group and the progressive disease group.@*RESULT@#The expression of EGFR and NF-kappaB were detected in human nasopharyngeal carcinoma tissues, which were not in normal ones. EGFR and NF-kappaB were significant difference of the radiosensitivity in nasopharyngeal carcinoma tissues (P0.05). The two factors' expression had negative correlation with radiosensitivity.@*CONCLUSION@#EGFR and NF-kappaB, as important targets, could predict the radiosensitivity of NPC, which could be helpful for targeting treatment and promote the effect of radiotherapy of NPC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Radiation Tolerance
/
Radiotherapy
/
Nasopharyngeal Neoplasms
/
NF-kappa B
/
ErbB Receptors
/
Metabolism
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2009
Type:
Article
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