Significances of COX-2, p21, Ki-67 expression and HPV infection in nasal inverted papilloma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 1823-1827, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-748800
ABSTRACT
OBJECTIVE@#To investigate the significance of expression of COX-2, p21, Ki67 and HPV in nasal inverted papilloma.@*METHOD@#Detecting COX-2, p21, Ki-67 in 30 cases of nasal inverted papilloma (NIP), 20 cases of nasal polyps (NP) and 10 cases of normal nasal mucosa (NM) by two step immunohistochemical method, and HPV virus by flow-through hybridization method.@*RESULT@#The positive expression rate of COX-2 and Ki-67 in NIP, NP and NM group was decreased in turn, COX-2 had significant difference in the groups(χ2 = 30.00, P< 0. 05); the positive expression rate of Ki-67 had significant differences between NIP and NM group (χ2 = 8. 533, P<0. 05). The expression of COX-2 in NIP tissues was positively correlate with that of Ki-67 by using Spearman rank correlation analysis (r=0.78, P<0.05). Expression of p21 were not observed in NIP group. The positive rate of HPV was 26. 67% in 30 cases of NIP, all of HPV16 type.@*CONCLUSION@#COX-2, Ki-67 and HPV infection have certain correlation with the occurrence of NIP. The occurrence of NIP has relationship with inflammatory reaction mediated by COX-2. Ki-67 can well reflect the proliferation activity of tumor cells, and can be used to measure the proliferation rate of nasal inverted papilloma. The COX-2 and Ki-67 have a synergistic role in the pathogenesis of NIP. p21 has no significant relationship with the incidence of NIP. HPV infection is related to the pathogenesis of NIP, but not as a;major factor in the pathogenesis of NIP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Case-Control Studies
/
Nasal Polyps
/
Nose Neoplasms
/
Papilloma, Inverted
/
Ki-67 Antigen
/
Papillomavirus Infections
/
Cyclooxygenase 2
/
Cyclin-Dependent Kinase Inhibitor p21
/
Genetics
Type of study:
Observational study
/
Risk factors
Limits:
Humans
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2014
Type:
Article
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